Abstract
Glioma is a heterogeneous central nervous system (CNS) tumor group that encompasses different histological subtypes with high variability in prognosis. The lesions account for almost 80% of primary malignant brain tumors. The aim of this study is to extend our understanding of the glioma epidemiology in the central Tunisian region. We analyzed 393 gliomas recorded in cancer registry of central Tunisia from 1993 to 2012. Crude incidence rates (CR) and world age-standardized rates (ASR) were estimated using annual population data size and age structure. Statistic correlations were established using Chi-square and Kaplan-Meier test. Tunisian glioma patients were identified with a mean age at diagnosis of 48 years and 1.5 sex ratio (male/female). During the 19 years period of study the highest incidence value was observed in male group between 1998 and 2002 (CR: 0.28, ASR: 0.3). Incidence results underline increasing high grade glioma occurring in the adulthood in the last period (2007-2012). Median survival was 27 months, with 1-, 2- and 5-year survival rates of 42%, 30% and 26%, respectively. Survival was greater in patients with younger age, lower tumor grade, infratentrial tumor location and undergoing a palliative treatment. This central Tunisia gliomas registry study provides important information that could improve glioma management and healthcare practice.
Highlights
Gliomas are primary central nervous system (CNS) tumors with glial cell origin
The aim of this study is to extend our understanding of the glioma epidemiology in the central Tunisian region
Incidence results underline increasing high grade glioma occurring in the adulthood in the last period (2007-2012)
Summary
The international classification of glioma (International Classification of Diseases for oncology: ICD-O-3) in based on the stem cell type that the tumor originates from (astrocytic or oligodendroglial) (Louis et al, 2001) They are subdivided according to their degree of malignancy into low or high grade gliomas(Louis et al, 2007). Over the last years epidemiological investigations of CNS tumors and Glioma led to collect many worldwild data and made it to the reach of all. The purpose of such investigations was to characterize glioma dissemination in numerous countries. Conclusions: This central Tunisia gliomas registry study provides important information that could improve glioma management and healthcare practice
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
