Abstract
Induction of neoplasia after therapeutic irradiation is well recognized. The development of the glioblastoma has been documented less frequently in association with radiation therapy. Pediatric patients with acute lymphoblastic leukemia are more susceptible to radiation-induced complications than adult patients. Post-radiation glioblastomas in childhood acute lymphoblastic leukemia have poor prognosis and are challenging for pediatric neuro-oncologists to treat due to manifesting more aggressive course than primary glioblastomas. To improve survival and quality of life new researches are required in the treatment of these patients. The goal of this review is to discuss the possible risk factors for radiation-induced tumorigenesis and histopathological characteristics.
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