Abstract
The aim of this study was to examine the protective effect of N-acetylcysteine (NAC) on testicular oxidative damage, spermatological parameters and DNA damage caused by Glyphosate (GLF) in rats. In total, twenty-eight Wistar male rats were evaluated by being separated into four groups in an equal way. Rats in group I, which represented the control group, were fed normal diet without GLF or NAC, group II received normal feed containing 160 mg/kg/daily NAC, group III received normal feed containing 375 mg/kg/daily GLF, and group IV received normal feed containing 160 mg/kg/daily NAC + 375 mg/kg/daily GLF. GLF administration decreased sperm motility, abnormal sperm rate, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the rats’ testicular tissue. On the other hand, high malondialdehyde level and DNA damage were detected in the group administered with GLF. Besides, in histopathological terms, a decrease in sperm concentration and degeneration of sertoli cells were determined in the testicular tissue. NAC and NAC+GLF administration reversed lipid peroxidation and DNA damage induced by GLF, the activity of antioxidant enzymes and cell integrity in rats’ testis. The above-mentioned findings indicate that NAC reduces lipid peroxidation caused by GLF, improves the antioxidant defense mechanism and regenerates tissue damage in rats’ testis.
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