Abstract
Recent studies have shown that free d-serine, an agonist for the N-methyl- d-aspartate receptor, is present in the forebrain of rats. In the present study, we raised antibodies against d-serine and examined the distribution of both endogenous and intracerebroventricularly administered d-serine in the rat forebrain by an immunocytochemical method. d-Serine-like immunoreactive cells were found in glial cells in the brains of the rats injected with d-serine into the lateral ventricle. No immunoreactive cells were seen in the brains of untreated rats. The results suggest that glial cells may accumulate and catabolized d-serine to regulate the concentration of this neuroactive amino acid in the forebrain.
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