Abstract
Vertebrate macroglial cells have diverse roles in the maintenance of neurological function. This review highlights progress in our understanding of the mechanisms that underlie the specification of precursors for two key macroglial subtypes — oligodendrocytes and astrocytes — in the embryo. These mechanisms are strikingly similar to those that underlie the development of neuronal subtypes, including emergence from localized regions of the neural tube, and involvement of common signalling pathways and downstream transcription factors. The switch from neuronal to glial precursor production can be modelled as a complex interplay between regionally-restricted components and generalized temporal regulators.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.