Abstract
Spinal Cord injury represents, in veterinary medicine, most of the neurological attendances and may result in permanent disability, death or euthanasia. Due to inflammation resulting from trauma, it originates the glial scar, which is a cell interaction complex system. Its function is to preserve the healthy circuits, however, it creates a physical and molecular barrier that prevents cell migration and restricts the neuroregeneration ability. This review aims to present innovations in the scene of treatment of spinal cord injury, approaching cell therapy, administration of enzyme, anti-inflammatory, and other active principles capable of modulating the inflammatory response, resulting in glial scar reduction and subsequent functional improvement of animals. Some innovative therapies as cell therapy, administration of enzymes, immunosuppressant or other drugs cause the modulation of inflammatory response proved to be a promising tool for the reduction of gliosis. Those tools promise to reduce gliosis and promote locomotor recovery in animals with spinal cord injury.
Highlights
Spinal Cord injury represents, in veterinary medicine, most of the neurological attendances and may result in permanent disability, death or euthanasia
Regardless of the cause, Spinal Cord Injury (SCI) are related to injury, compression, transaction, laceration, traction of the neural tissue, hemorrhage and hematoma, hypoxia, spinal cord laceration or the associated roots and others injuries resulting in varying degrees of neurological disorders[1,2]
The consequences of SCI in veterinary medicine, depending on the injured segment can lead to permanent disability or euthanasia
Summary
Ahmed et al.[30] Do-Thi et al.[35] Yick[36], Xia et al.[37], Huang et al.[38], Ni et al.[39] Bonner et al.[41], Jin et al.[42], Mitsui et al.[43] Huang et al.[27]
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