Abstract
The Drosophilaglial cells missing (gcm) gene is not only essential for generating embryonic glial differentiation but also necessary and sufficient for generating glial cells during the postembryonic stage. However, the mechanisms of how the gcm gene is mediated are still elusive. This study reveals that gcm was expressed with fluctuating variation during the third instar larval and pupal stage, the 20-hydroxyecdysone (20E) treatment can upregulate gcm expression, the knockdown of EcR-A and USP1 led to a reduced transcript level of gcm in S2 cells. These results suggest that the 20E signaling pathway can mediate gcm expression through the 20E receptor EcR-A and its heterodimer USP1.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.