Glia-neuronal transitions in development: significance in medical research and treatment of pathologies

Abstract

The questions of how autonomic neurons and their fibers select the target organs and whether parasympathetic innervation affects the development and growth of diverse organs are still open. We hypothesize that glia-neuronal transitions in development is crucial for correct development and homeostasis of innervated tissues in mice. The result of this preliminary experiment using genetic tracing showed that the mice mutants with lack autonomic ganglia indeed have a problem with development of target organs and support idea that autonomic nervous system directly involved in innervated organs morphogenesis.