Abstract
Glia (including astrocytes, microglia and oligodendrocytes), which constitute the majority of cells in the brain were thought to function as passive supportive cells, bringing nutrients to and removing wastes from the neurons. Glia cells have almost the same receptors as neurons, secrete neurotransmitters, neurotrophic and neuroinflammatory factors and are intimately involved in synaptic plasticity. Glia has been found to have multiple functions in eventually all systems of the body (CNS, CVS, GIT etc) Considering the multiple functions of glia, and because glia are the most numerous cells in the brain, it is not surprising that psychostimulants affect their activity. Thus, this review is focused on works done to reveal the important roles played by glia in addiction and the possibility of manipulating the activity of glia as a target in the development of pharmacotherapeutic agents for treating disorders related to psychostimulants.
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