Abstract
GLI1 finds a new role in cancer stem cell biology
Highlights
In this issue, a study by Goel and colleagues defines a novel pathway regulating the biology of tumour initiating cells in triple negative breast cancers (Goel et al, 2013) (Fig 1)
NRP2, a neuronal receptor involved in axon guidance (Uniewicz & Fernig, 2008), is highly expressed in human breast cancer and correlates with aggressive disease and poor clinical outcome, features of triple negative breast cancer
Further characterization of the mechanism identified NRP2 and BMI1 as direct targets of GLI1, which binds to the promoter of these molecules to regulate their expression
Summary
A study by Goel and colleagues defines a novel pathway regulating the biology of tumour initiating cells in triple negative breast cancers (Goel et al, 2013) (Fig 1). Goel et al have identified a novel cascade downstream of the VEGF receptor Neuropilin-2 (NRP2) regulating the biology of tumour initiating cells (Fig 1).
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