GLI is a better predictor of airway obstruction in young, asymptomatic patients with Marfan syndrome

Abstract

Marfan syndrome is a genetic disorder of the connective tissue, including involvement of the lungs. Pulmonary function test was performed in 33 asymptomatic adult Marfan patients using European Community for Coal and Steel (ECCS) and Global Lung Function Initiative (GLI) reference values. Using GLI equations for reference, significantly lower lung function values were noted for forced vital capacity (FVC) (87.02±16.62 vs. 97.11±16.89; p Airway obstruction is dependent on reference equations used in Marfan patients. GLI reference equations are more suitable to evaluate lung function changes in patients with connective tissue disorders.