Abstract
This essay reviews the discipline‐connecting potential of experimentation. Two examples are used to illustrate how researchers in the first half of the twentieth century profitably combined resources from different disciplines in their experiments. These experiments were designed to test mechanism models describing chemical processes underlying the behavior of biological systems. The researchers had clear expectations about how certain interventions should affect the behavior of the organisms studied, if that behavior was indeed based on the presumed chemical processes. They manipulated the organisms in the relevant ways and determined how the behavior of the organisms changed as a result.
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