Abstract
S-2-(3-tert-Butylamino-2-hydroxypropoxy)-3-cyanopyridine was recovered (∼90%) from human plasma and detected by conversion to a diheptafluorobutyryl derivative for electron-capture GLC. A homolog served as an internal standard. The method measures plasma drug concentrations at the 5-ng/ml level and is suitable for plasma analysis from humans who receive a therapeutic oral dose.
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