Abstract
We have recently reported the discovery of an oncolytic IgA/IgG heterodimeric, bispecific immunoglobulin generated by exfoliated colonic cells isolated from stool samples of free living subjects (EB 2019, Orlando. Florida). We isolated these cells from stool samples (0.5 gm) of a cohort of 60 free‐living subjects using our SCSR technology and labelled them with fluorescently tagged antibodies to IgA/IgG and analyzed them by flow cytometry to detect the co‐expression of the chimeric GIPSITUMABTM. We found two subjects in this group without any evidence of this chimeric antibody. On unblinding the data‐set we found that these two subjects were of African‐American descent. Unlike the cells from a few other individuals in this group, these cells upon culturing in stem cell growth medium confirmed the absence of this antibody in their progeny. Our observations appear to show the existence of a syndrome in which this immunoglobulin is not expressed and may be indicative of a germ‐line deletion signalling the presence of an increased risk for developing a malignancy.Support or Funding InformationSupported in part by US National Institutes of Health, SBIR Grants, R44CA81799 and R44DK56567
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