Abstract
Materials and methods This was an observational, descriptive and cross-sectional study. A total of 222 subjects (129 women, 93 men) were recruited from the University Hospital located in a Brazilian metropolitan area (approximately 1.067,214 inhabitants). Random stratification was performed considering gender and geographic regions (downtown, north, south, east, west and other metropolitan areas). Data were collected by personal interview
Highlights
Glucose-dependent insulinotropic polypeptide receptor (GIPR) is mainly found in the pancreatic beta cells but has systemic distribution and function
The C mutant allele was found in 27% of the population studied, with higher prevalence in men (p=0.006; odds ratio (OR)=0.44), in caucasians (p=0.0001; OR=0.28) and in hypertensive subjects (p=0.004; OR=0.40)
No significant associations were found between the single nucleotide polymorphism (SNP) and body mass index, obesity, diabetes and family history for metabolic syndrome-related diseases
Summary
Glucose-dependent insulinotropic polypeptide receptor (GIPR) is mainly found in the pancreatic beta cells but has systemic distribution and function. Some genetic GIPR variants were recently associated with obesity, diabetes and insulin resistance. Few studies had studied the genetic epidemiology of the GIPR, mainly in Europe
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
