Abstract
Aim To prepare and characterize a 6-gingerol-incorporated chitosan biopolymerfor coating on thermoformed aligners and evaluate its scratch resistance andantimicrobial activity. Material and methods In this in vitro study, 6-gingerol extract was prepared, incorporated with chitosan biopolymer into a coating solution and characterized using nuclear magnetic resonance imaging spectroscopy (NMR). Twenty thermoformed aligner samples were exposed to UV radiation for surface activation, then coated with a crosslinking agent. These were divided into four groups of five. The control group consisted of samples dip-coated in a chitosan solution for 15 minutes. The three test groups consisted of samples dip coated in a gingerol-chitosan coating solution, with each group representing the following time periods of dip coating: five, 10, and 15 minutes. The crosslinking of the coating with the aligner material was confirmed by a Fourier transform infrared spectroscopy (FTIR) test. A scratch test was carried out to evaluate the wear resistance of the coating, and the antibacterial properties of the coating were tested using a Disc Diffusion test. Results The NMR analysis confirmed the presence of 6-gingerol in the extract. The coating of 6-Gingerol on aligners was confirmed by FTIR spectroscopy. The wear resistance of aligners coated for 5 minutes, 10 minutes, and 15 minutes was 1.8 ± 0.09N, 2.3± 0.021 N, and 3.06 ± 0.17N, respectively, and the difference was statistically significant (p<0.05). The aligner coated for 15 minutes exhibited the widest zone of inhibition of up to 2.38 ± 0.44 mm against Streptococcus mutans, and the difference wasstatistically significant (p<0.05).No antibacterial effect was found against E. Coli. Conclusion A novel coating material with 6-gingerol extractincorporated in chitosan biopolymer was prepared and characterized, followed by coatingon thermoformed aligners. The coating showedantibacterial activity againstStreptococcus mutans,and both the antimicrobial activity and wear resistanceincreased with coating duration.
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