Abstract
Zingiber officinale Roscoe and Citrus limon L. are well known for their multi-use and for their pharmacological effect in the treatment of many illnesses. This study aims to investigate the chemical composition of the ginger and lemon juice extracts and in addition, to evaluate their antioxidant properties and their hepatoprotective effect against the liver damage of Wistar rats induced by the injection of CCl4 to treated animals. The obtained effects were completed by a histological study for better confirmation of the registered pharmacological effects. The ginger juice extract was found to be rich in 4-gingerol, 6-gingediol, and 6-gingerol, while the lemon juice extract chemical composition was highlighted by the presence of eriodyctiol, rutin, hesperidin, and isorhamnetin. Concerning the antioxidant activity, the ginger, lemon juice extracts, and their formulation showed an important antioxidant potential using TAC (total antioxidant capacity), an antiradical activity against the radical DPPH• (2,2-diphenyl-1-picrylhydrazil), and a ferric reducing power. Finally, the ginger, lemon, and their formulation at different doses were able to prevent CCl4 induced liver damage. Indeed, these different bioactive compounds could be used as alternative agents for the treatment of chronic liver diseases.
Highlights
The determination of the total polyphenol content of the different extracts of ginger and lemon juices showed that the different extracts GJ and LJ contained a significant amount of polyphenols
These formed radicals are disactivated through the intrinsic antioxidant system which plays a crucial role in detoxifying the body from the production of radicals that occurs during the biochemical process [29]
The finding of the present study revealed that ginger and lemon juices and their formulation are endowed with a significant antioxidant potential which was evaluated using the free radical DPPH, the ferric reducing power assay (FRAP), and the total antioxidant capacity (TAC)
Summary
Introduction iationsThe liver is a large gland that performs numerous functions including principally metabolic functions, and biliary secretion, xenobiotic detoxification, and excretion [1].its integrity is threatened by several toxic external agents (drugs, industrial products, heavy metals, etc.), which can cause cirrhosis, steatosis, necrosis, which are generally grouped under the term hepatotoxicity [2].In general, acute or chronic exposure to hepatotoxic agents results in a destabilization of the hepatic pro/antioxidant balance because of the excessive production of free radicals.These free radicals can alter any type of molecules or cells, causing very serious damage that may be irreversible in the long term, whether at the structural or functional level [3].a good condition of the liver is essential for maintaining the body’s homeostasis, since the liver is a crucial metabolic crossroads in the functioning of the body. Acute or chronic exposure to hepatotoxic agents results in a destabilization of the hepatic pro/antioxidant balance because of the excessive production of free radicals. These free radicals can alter any type of molecules or cells, causing very serious damage that may be irreversible in the long term, whether at the structural or functional level [3]. A good condition of the liver is essential for maintaining the body’s homeostasis, since the liver is a crucial metabolic crossroads in the functioning of the body
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
