Ginger (Zingiber officinale ) ameliorates metalexyl fungicide induced kidney damage in albino mice

Abstract

The work extends to study the possible role of the aqueous extract of Ginger (Zingiber officinale) in minimizing the toxicity of metalaxyl. Animals were divided into 4 groups. Group 1: given metalaxyl at a dose level of 1/10 LD50 for 4 weeks, Group 2: given metalexyl and ginger, Group 3: given ginger and Group 4: controls. Histopathological and biochemical observations of the kidney functions parameters and oxidative enzymes were carried out. Kidney cortex of metalexyl‐treated mice showed many histopathological alterations. Metalexyl caused marked elevation in serum creatinine and blood urea nitrogen. Moreover, metalaxyle administration to animals significantly increased malondialdehyde and decreased superoxide dismutase (SOD) and catalase activity. Treating animals with metalexyl and ginger led to an improvement in the histological structure of the kidney together with significant decrease in urea and creatinine. Moreover, ginger reduced the level of serum malondialdhyde and increased the serum level of antioxidant enzymes, SOD and catalase. The results indicated that ginger had ameliorative effect against kidney damage induced by metalexyl and this may be mediated by its potent antioxidant activities. The present work is supported by Umm Al‐Qura University and Menoufia University.