Ginger Treatment Ameliorates Alcohol‐Induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats

Abstract

BackgroundAlcohol‐induced hyperlipidemia is positively correlated with cardiovascular diseases. Several herbal extracts are reported to protect the cardiac injury and suppress the hyperlipidemia. However, the effect of ginger on alcohol‐induced hyperlipidaemia and myocardial damage remains unclear.ObjectiveThis study investigated the cardio protective properties of ginger ethanolic extract (Gt) on alcohol‐induced myocardial damage, and further distinguished the association between hyperlipidemia and occurrence of myocardial damage in rats.Materials and MethodsTwenty four Wistar male albino rats weighing 250 ± 20 g were divided into four groups includes, Normal control (NC) (0.9% NaCl), Ginger treated (Gt) (200 mg/Kg b.w.), Alcohol treated (At) (20%, 6 g/Kg b.w.) and Alcohol along with Ginger treatment(At+Gt). In this study, lipid profiles such as fatty acids, triglycerides, total cholesterol, phospholipids, low density lipoprotein and high density lipoproteins and Cardiac biomarkers includes LDH, AST, CK‐MB, cTn‐T and cTn‐I were examined in rats. In addition, histopathological studies were also conducted.ResultsWe found alcohol‐induced myocardial damage was associated with increased lipid profile except high density lipoprotein in alcohol treated (6 g/kg b.w.) rats compared to control rats while ginger treatment (200 mg/kg b.w.) reduced the lipid profiles except high density lipoproteins. Furthermore, elevated cardiac biomarkers activities with alcohol intoxication were significantly suppressed by ginger treatment. In addition, ginger treatment significantly minimized the myocardial damage induced by alcohol.ConclusionOur results conclude that ginger could protect from alcohol ‐ induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers.Support or Funding InformationUGC‐MRP‐F.No43‐586/2014(SR) dated 30‐10‐2015