Abstract
Introduction: Pro inflammatory cytokines produced primarily by macrophages are key elements in many surgical conditions including sepsis, ischemia-reperfusion injury and transplant rejection. Ginger, a widely used botanical for its postulated anti-inflammatory properties, and its active ingredient, 6-gingereol, appears to inhibit macrophage function through NFkB signaling in murine macrophages. Since NFkB is involved in the regulation of pro-inflammatory cytokine production from macrophages, we hypothesized that both ginger extract and 6-gingerol will inhibit LPS stimulated liberation of these cytokines from macrophages.
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