Gilbert's Disease: Symptomatic Response to Nutritional Supplementation in Ten Patients

Abstract

This paper reports on 10 patients who were found from routine laboratory studies to have Gilbert's syndrome (GS), also known as benign hyperbilinibinemia. Each patient came to our clinic with multiple symptoms which appear to have become increasingly common in the population of the USA as a whole. Each received only nutrient therapy and symptomatic improvement was generally experienced by all of them. Although we observed a gradual decrease of serum bilirubin to normal in three of the patients, it is known that patients with this syndrome experience fluctuations in concentration of serum bilirubin which can be in the normal or abnormal range at different times. the many symptoms reported in GS are not specific to the syndrome and are experienced by individuals with normal serum bilirubin concentrations.