Abstract
Background: Nano-formulations of various drugs and natural compounds are becoming popular day by day. A number of cosmetic, medicinal and herbal products are formulated using nano-carriers. However, one of the concerns using these carriers is the alteration in morphology of cell by using such particles or droplets. Methods: In the present work, Giemsa staining was used to study the morphological changes on mammalian Neuro-2a cell line upon treatment with prepared capsaicin loaded nanoemulsion (Caps-NE), baclofen loaded poly(lactic-co-glycolic acid) nanoparticles (Bcf-PLGA-NPs) and lamotrigine loaded poly(lactic-co-glycolic acid) nanoparticles (Ltg-PLGA-NPs). Caps-NE, Bcf- PLGA-NPs and Ltg-PLGA-NPs, along with their respective aqueous drug counterparts, were examined for visible morphological changes at their corresponding reported maximum plasma concentration (Cmax) and 10xCmax values. Results: Microscopic images showed that drug loaded nanoemulsion/nanoparticles showed comparable cell viability and exhibited lesser cytotoxicity than the available aqueous drug forms at both the concentrations. Conclusion: The prepared formulations can be used as potentially safer option as compared to their aqueous counterparts.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
