Gibt es eine antiinflammatorische Therapie der Adipositas?

Abstract

Obesity is characterized as a state of low-grade chronic inflammation which is originating from the biochemical and cellular alterations in the expanded adipose depots, particularly in the intraabdominal cavity. The adipose tissue of obese subjects exhibits an infiltration by activated lymphocytes and monocytes / macrophages which is augmenting the local inflammation. In the peripheral blood, elevated concentrations of „adipokines” such as leptin, IL-6, IL-8, MCP-1 and others as well as lower levels of the anti-inflammatory adiponectin are detectable. This inflammatory state represent an ideal soil for the development of insulin resistance and other disturbances which may explain the link between obesity and its metabolic and cardiovascular complications. Dietary intervention studies indicate that substantial weight loss has the greatest effect on these disturbances which appear to be largely reversible. There is growing evidence that a diet with a low content of saturated fat and trans fatty acids, a high content of plant products and a high intake of n-3 fatty acids may have some beneficial modulatory effect on adipose tissue inflammation. However, our understanding of these interactions is still rather limited, but this area clearly is a challenge for nutrition research in the next future.