Abstract
T-wave changes in electrocardiogram frequently accompany conditions related to myocardial ischemia. A variety of other events are also known to result in giant T-wave inversion (GTWI). The advanced stages of chronic kidney disease carries a cluster of several traditional and uremia-specific cardiovascular risk factors and is associated with risk for electrolyte imbalance and venous thromboembolism, all being the possible reasons for GTWI. GTWI presents a diagnostic challenge for physicians. Medicine specialists should beware of overly one-sided clinical attention and consider diverse and complex basis of the observed signs and symptoms.
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