Giant Sinonasal Ameloblastoma

Abstract

Ameloblastoma is well recognized as a locally invasive benign neoplasm thought to arise from the cellular components of the enamel organ. Broca described ameloblastoma in 1868 [1]. Ameloblastoma contributes to about 1 % of all head and neck tumors and 13 to 58% of all odontogenic tumors [2]. Maxillary ameloblastoma is rare and account for 15% of all ameloblastomas. Slow-growing, painless swelling of the mandible or maxilla is the most common presentation of ameloblastoma and the diagnosis requires imaging (CT scan). Mutations in genes that belong to the mitogen-activated protien kinase MAPK pathway are found in many ameloblastomas, the most common being the BRAFV600E mutation [3].