Giant pseudopolyposis in ulcerative colitis: Case report and review of literature

Abstract

Localized giant pseudopolyposis is an extremely rare feature of pseudopolyposis complicating inflammatory bowel disease. It represents a localized exuberant collection of pseudopolyps, which may simulate neoplasms such as polypoid cancer.We report a case of a 23-year-old man with the diagnosis of ulcerative colitis, who presented with symptoms of subacute large bowel obstruction. At colonoscopy a large polypoid lesion was found in the transverse colon, causing almost complete luminal obstruction. The patient underwent an extended right hemicolectomy and the surgical specimen examination showed multiple pseudopolyps corresponding to exuberant glandular hyperplasia with mucosal dense mixed cell transmural infiltrate with no dysplasia or malignancy. The diagnosis of giant inflammatory polyposis associated with inflammatory bowel disease was therefore made.