Giant ovarian immature teratoma with bilateral mature teratoma: case report

Vanderson J L Dan,Valdir R Martins Júnior,André Genaro,Raquel Zacharias

doi:10.11606/issn.2176-7262.v49i5p483-489

Abstract

Immature teratoma of the ovary is a malignant neoplasm composed of undifferentiated tissue that arises from embryonic cells. And the mature teratoma is a benign neoplasm composed of differentiated tissues. This paper aims to report the case of a 21-year-old pacient with giant immature teratoma in left ovary associated with mature ovarian teratoma bilateral, due to the association of teratoma with mature teratoma ipsilateral and contralaterally, combined with its outstanding increased size (36 cm), is unusual. Exploratory laparotomy, with cytoreductive pan-hysterectomy and bilateral salpingooferectomia were performed. The patient received adjuvant chemotherapy with BEP regimen (bleomycin, etoposide and cisplatin) in four cycles with intervals of 21 days, coursing with good evolution

Highlights

Immature teratoma of the ovary is a malignant neoplasm composed of undifferentiated tissue that arises from embryonic cells
This paper aims to report the case of a 21-year-old pacient with giant immature teratoma in left ovary associated with mature ovarian teratoma bilateral, due to the association of teratoma with mature teratoma ipsilateral and contralaterally, combined with its outstanding increased size (36 cm), is unusual
O que, além do desconforto, pode afetar o prognóstico, posto que, como referido, a identificação do teratoma imaturo em estágios mais precoces e com menores tamanhos permite melhores resultados e uma melhor sobrevida às pacientes!

Summary

Introduction

Immature teratoma of the ovary is a malignant neoplasm composed of undifferentiated tissue that arises from embryonic cells. Marcadores tumorais requeridos na avaliação de pacientes com teratoma incluem subunidade β da gonadotrofina coriônica humana (β-HCG) e alfa feto-proteína (AFP),[4] pois, muito embora os teratomas maduros geralmente não causem elevação desses marcadores e os imaturos se relacionem mais com a AFP (elevada em 65% dos casos), auxiliam na exclusão de outras neoplasias de células germinativas.[11,12,13]

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