Abstract
46-year-old man with a clinical diagnosis of dilated phase of hypertrophic cardiomyopathy was followed up at our hospital for 26 years. His refractory congestive heart failure gradually worsened over several years, and he was unresponsive to conventional medications. He then underwent left ventriculoplasty. Biochemical and genetic investigations of the left ventricular myocardium revealed a novel point mutation in the mitochondrial DNA.1 Scanning electron microscopy can directly observe both the 3-dimensional structure of a cell with high resolution and the 3-dimensional structure of the membrane system using the osmium-dimethyl sulfoxide-osmium method2 to remove the cytoplasmic matrix. Conventional transmission electron microscopy …
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