Giant Gastrointestinal Stromal Tumors

Abstract

Gastrointestinal stromal tumors in interstitial Cajal cells of myenteric plexus of the muscularis propria are the commonest gastrointestinal mesenchymal tumors, not exclusively, appearing in the stomach. This case report documents management of a giant gastric stromal tumor of a 75 year-old female patient presented with generalized, vague, constant abdominal pain and melena, both of a week’s duration. She had early satiety with dizziness, feeling weak, and fatigue. She had a good appetite and no weight loss, hematemesis, or vomiting. She was apyrexial, with normal vital signs. The abdomen was soft, with a palpable large mass in epigastrium and central abdomen; an abdominal CT showed a heterogeneous mass lesion of antrum of stomach. Subtotal gastrectomy with roux-en-y gastrojejunostomy was performed. Histopathology showed epithelioid high grade gastrointestinal stromal tumor. The cornerstone therapy is a full operative removal of the tumor, with adjuvant therapy with selective receptor tyrosine kinase inhibitors.