Giant Dermatofibroma Appearing During Pregnancy

Abstract

Sir, Dermatofibroma (DF) is a common benign fibrohistiocytic neoplasm that usually occurs in mid-adult life and shows a slight female predominance. DF may represent a dermal response to a local injury such as an insect bite, rupture of a follicle or a follicular cyst and typically appears as a slow-growing, firm solitary papule, more rarely a plaque or nodule, preferentially located on the lower extremities. The colour varies from light brown to dark brown, red, purple or yellow, and the surface may be shiny or keratotic. DF is often asymptomatic, although pruritus and/or ulceration following trauma may be present. On palpation, the lesion is freely movable over deeper tissues, and lateral compression produces a dimple-like depression in the overlying skin. Several uncommon clinical variants of DF have been reported, including giant DF (1) and multiple DF (2). The prototypic dermoscopic pattern of DF is a central white scar-like patch surrounded by a delicate light brown pigment network in an annular distribution or by a diffuse light brown pigmentation (3). We report herein the case of a young woman with an unusual clinical and dermoscopic presentation of giant DF characterized by a rapid growth during pregnancy.