Abstract
Purpose: To report a case of giant cobblestone-like papillae that appeared during oral isotretinoin therapy.Design: Case report.Methods: A 14-year-old boy presented with bilateral eye itching for 1 week. Bilateral upper palpebral conjunctival cobblestone-like papillae, superficial punctate keratitis, and shield ulcer in the left cornea were seen. At the time, he was treated with oral isotretinoin for 6 months.Results: Following cessation of isotretinoin, the ulcer and SPK healed, and the papillae disappeared completely after an 8-week course.Conclusion: Giant cobblestone-like papillae and corneal shield ulcer may be considered as a probable isotretinoin-induced ocular adverse event.
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