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Abstract
IntroductionGiant cell reparative granuloma is a rare, locally benign tumor with an aggressive behavior resembling malignant neoplasm, originating mainly from the mandible and maxilla; however, it can originate from other sites, such as zygomatic and temporal bones, with a young adult female predilection. Case presentationA 28-year-old female presented to the Department of Otolaryngology and Head and Neck Surgery with a history of a slowly enlarging swelling over the left parotid region for four months. Physical examination revealed a non-erythematous, non-tender, firm mass with no overlying skin changes. Fine needle aspiration cytology of the lesion revealed a multinucleated giant cell-rich tumor and the histopathological examination of an incisional biopsy from the mass confirmed giant cell reparative granuloma. Therefore, a total surgical excision of the mass with curating of the zygomatic and temporal bones was performed with uneventful postoperative course and regular follow ups for one year. ConclusionA growing mass in the parotid region in a young adult female with no history of trauma should raise the suspicion of giant cell reparative granuloma. Histopathological examination is the definitive tool for diagnosis, and surgical excision is the treatment modality of choice in such cases.
Highlights
Giant cell reparative granuloma is a rare, locally benign tumor with an aggressive behavior resembling malignant neoplasm, originating mainly from the mandible and maxilla; it can originate from other sites, such as zygomatic and temporal bones, with a young adult female predilection
We present a full clinical picture of a case with Giant Cell Reparative Granuloma (GCRG) of the zygomatic bone along with the investigations conducted for reaching the definitive diagnosis, in addition to the way of management and postoperative outcome
Regarding age of GCRG occurrence, it is reported in the literature to affect mainly children as an unknow etiology as well as young adult females due to hormonal dependence suggested by a flare-up and recurrence during pregnancy [3]
Summary
Giant Cell Reparative Granuloma (GCRG) was first described by Jaffe in 1953 as a rare, benign, locally aggressive tumor of the bone, originating mainly from the mandible and maxilla [1]. As a result of the associated symptoms, as well as, the radiological findings of such cases being non-specific, the definitive diagnosis relies mainly on a histopathological examination of a biopsy taken from the mass. We present a full clinical picture of a case with GCRG of the zygomatic bone along with the investigations conducted for reaching the definitive diagnosis, in addition to the way of management and postoperative outcome. To the best of our knowledge, there has been only one reported case in the literature of a GCRG of a parotid region infiltrating the zygomatic bone [4]. This work has been reported in line with SCARE criteria [5]
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