Giant Cell Granuloma of the Anterior Skull Base: Need for Early, Maximal Surgical Excision: A Short Series of 3 Cases with Review of Literature.

Abstract

Giant cell granuloma is a rare benign granulomatous lesion of the bone. The local aggressiveness, potentiation with trauma and complex anatomy of the skull base makes the surgical management in this location challenging. We report a series of three cases along with the clinical presentation, radiological and histopathological findings and the management issues while dealing with this lesion. A review of literature reveals the rarity of the lesion, alternate management modalities and the outcomes for such lesion involving the jaw bones and the skull base. For best outcomes differential diagnosis from giant cell tumor and brown tumor of hyperparathyroidism is essential. Further it may be concluded that there is a need for maximal surgical excision to avoid recurrence as the second line management options are not as effective.