Abstract
Ghrelin receptor controls obesity by fat burning.
Highlights
white adipose tissue (WAT) and brown adipose tissue (BAT) have distinct characteristics and functions
Our findings indicate for the first time that ghrelin signaling plays an important role in thermogenesis during aging; Growth Hormone Secretagogue Receptor (GHS-R) regulates energy homeostasis by burning fat to generate heat, not by reducing long term energy intake
This challenges the dogmatic view of ghrelin’s regulation of lipid metabolism via its orexigenic property, and reveals an exciting possibility that suppressing ghrelin signaling may protect against age-associated obesity by enhancing thermogenesis
Summary
WAT and BAT have distinct characteristics and functions. WAT stores energy as triglycerides in large unilocular lipid droplets; WAT supplies energy to the body via lipolysis. 2) Ablation of GHS-R enhances increases DNA and protein synthesis of mitochondria, increasing mitochondrial biogenesis. 3) Ablation of GHS-R augments mitochondrial dynamics, enhancing both mitochondrial fission and fusion; this restores mitochondrial architecture and improves mitochondrial homeostasis. GHS-R ablation increases thermogenesis in BAT by activating thermogenic signaling, increasing mitochondrial biogenesis, and enhancing mitochondrial dynamics.
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