Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Suleyman Aydin,Suna Aydin,Gerry Croteau,Íbrahim Sahin,Cihan Citil

doi:10.2478/v10011-010-0009-8

Suleyman Aydin, Suna Aydin + Show 3 more

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https://doi.org/10.2478/v10011-010-0009-8

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Abstract

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant WorkersOccupational cement dust exposure has been associated with an increased risk of liver abnormalities, pulmonary disorders, and carcinogenesis. Decreased antioxidant capacity and increased plasma lipid peroxidation have been posed as possible causal mechanisms of disease. Accordingly, this study examined the serum paraoxonase (PON1) arylesterase (AE), ghrelin, HDL-C, LDL-C and serum nitrite (NOx) levels in cement dust exposed workers. Twenty-eight volunteer male cement plant workers and 30 volunteer control male workers, aged 29-54 years, participated. The concentrations of serum PON1, AE, NOx, ghrelin, and HDL-cholesterol and LDL-cholesterol were measured in both groups. PON-1, AE, ghrelin and HDL-cholesterol were lower in the cement plant workers than in controls. Serum nitrite (NOx), and LDL-C levels in cement plant workers were higher (p<0.05) than in the control group workers. No correlation was observed between the serum levels of HDL-cholesterol and PON1 and between HDL-cholesterol and ghrelin. A weak negative correlation was detected between the serum ghrelin and NOx. The study results strongly suggest that HDL-paraoxonase, AE, ghrelin, HDL-C, and high NOx, and LDL-C levels may have a role in disease involving oxidative damage. However, some studies are necessary to address the association between occupational dust exposure and respiratory symptoms.

Highlights

Cement, in particular portland cement, is widely used by the construction industry as a building material [1]
The concentrations of serum PON1, AE, NOx, ghrelin, and HDL-cholesterol and low density lipoprotein (LDL)-cholesterol were measured in both groups
No correlation was observed between the serum levels of HDL-cholesterol and PON1 and between HDL-cholesterol and ghrelin

Summary

Introduction

In particular portland cement, is widely used by the construction industry as a building material [1]. The accompanying growth in world wide cement production has increased JMB 2010; 29 [2]. The number of workers exposed to airborne cement dust. Worker exposure occurs primarily through the respiratory route, but dermal exposure can result in adverse health effects. There are numerous reports on the adverse health effects of cement dust in both animals [2], and humans [3,4,5,6,7,8,9]. Liver abnormalities [4], pulmonary disorders [2], carcinogenesis [5,6,7,8], decreased antioxidant capacity and increased plasma lipid peroxidation have been reported among cement factory workers [9]

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