Abstract
Ghrelin Attenuates Brain Injury after Traumatic Brain Injury and Uncontrolled Hemorrhagic Shock in Rats
Highlights
Traumatic brain injury (TBI) remains a major public health problem globally [1,2,3,4,5]
Brain levels of IL-6 increased by 18% at 4 h after TBI and uncontrolled hemorrhage (UH) (P < 0.05)
We determined the efficacy of ghrelin in a highly military relevant experimental rat model of TBI combined with uncontrolled hemorrhagic shock
Summary
Traumatic brain injury (TBI) remains a major public health problem globally [1,2,3,4,5]. TBI resulting from either blast injury or vehicle accidents represents important issues for the combat medic. TBI, on the other hand, impairs shock compensation In this regard, a therapeutic intervention to treat posttraumatic hypotension and prevent secondary ischemia would be a powerful tool to improve outcome after brain injury. Our recent studies have shown that ghrelin ameliorates gut ischemia reperfusion or sepsis-induced organ injury and mortality via stimulation of ghrelin receptors in the brain [15,16,17,18]. Whether ghrelin attenuates brain injury following TBI and hemorrhagic shock remained unknown. The purpose of this study was to evaluate the efficacy of ghrelin using a highly military relevant experimental model of TBI combined with uncontrolled hemorrhagic shock in rats
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