GFAP astrocytopathy presenting with profound intracranial hypertension and vision loss

Abstract

BackgroundGlial fibrillary acidic protein (GFAP) astrocytopathy is a steroid-responsive autoimmune meningoencephalomyelitis commonly preceded by a viral illness. It is clinically characterized by encephalopathy, myelopathy and papillitis without significant effect on visual acuity. It can be associated with an underlying malignancy or autoimmune condition. ObjectiveTo report a novel case of GFAP astrocytopathy presenting with profound intracranial hypertension and bilateral vision loss. MethodsCase report. Results and conclusionGFAP astrocytopathy should be considered when evaluating patients with intracranial hypertension or bilateral vision loss, particularly when other features of autoimmune encephalitis are present.