Getting More Precise in Public Messaging on Scientific and Data Uncertainties for Precision Medicine Research.

Abstract

Precision medicine is defined as “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle” [1]. Launched in 2015, the Precision Medicine Initiative is a national research priority for advancing knowledge around disease risk and mechanisms, developing new diagnostics and treatments, assessing prognoses and predicting treatment responses, and creating prevention strategies that are tailored to individual genetic, environmental, and lifestyle factors [2]. To realize the vision of precision medicine, the All of Us Research Program began in 2016 with the goal of collecting, curating, and sharing health-related, biospecimen and patient-reported outcomes from more than 1 million volunteers by 2027 across the USA [2, 3]. The All of Us Research Program relies on volunteers’ willingness to freely provide their health data, participate in longitudinal health and behavioral assessments, permit tracking of geospatial and environmental data,...