Abstract
reported large variability in reports of musculoskeletal disorders, with rates of patients on AIs ranging from 5% to 35%. In the community, the rate of AI-related arthralgia appears to be higher. In a survey of 200 patients with breast cancer on adjuvant AI therapy, more than 40% of women reported worsening or new-onset joint pain or stiffness after starting AIs. 9 Among those with AI-related joint symptoms, about two thirds experienced moderate to severe symptoms. This variability reflects a critical issue with regard to clinical trial toxicity assessments and patient reported symptoms.
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