Abstract
Neuroscience Regulation of synaptic AMPA receptors (AMPARs) is a key process implicated in synaptic plasticity. Glutamate receptor interacting protein 1 (GRIP1) is a scaffolding protein that interacts directly with several members of the AMPAR family. GRIP1 regulates the surface expression and synaptic stabilization of AMPARs, but its role in the expression of long-term potentiation (LTP) is unknown. Tan et al. investigated the function of GRIP1 in LTP and its impact on learning and memory. GRIP1 was recruited into synapses with AMPARs. The GRIP1-AMPAR interaction was enhanced during LTP. Loss of GRIP1 blocked the activity-induced accumulation of synaptic AMPARs and mice deficient in Grip1 exhibited learning and memory deficits. These findings indicate an essential role for GRIP1 in synaptic plasticity and cognitive functions. Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.2014827117 (2020).
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