Abstract
Gestational hypoxia is a risk factor in the development of pulmonary hypertension in the newborn and other sequela, however, the mechanisms associated with the disease remain poorly understood. This review highlights disruption of metabolism by antenatal high altitude hypoxia and the impact this has on pulmonary hypertension in the newborn with discussion of model organisms and human populations. There is particular emphasis on modifications in glucose and lipid metabolism along with alterations in mitochondrial function. Additional focus is placed on increases in oxidative stress and the progression of pulmonary vascular disease in the newborn and on the need for further exploration using a combination of contemporary and classical approaches.
Highlights
Reviewed by: Vincent Joseph, Laval University, Canada Carmen Silvia Valente Barbas, University of São Paulo, Brazil
This review is centered on the disruption of metabolism by antenatal high altitude hypoxia and the impact this has on pulmonary hypertension in the newborn with discussion of issues that arise in human populations and the use of model organisms
We and others have found that hypoxia-induced pulmonary vascular disease, which occurs in human infants, can be recapitulated in fetal and newborn sheep from pregnant ewes living at high altitude
Summary
Reviewed by: Vincent Joseph, Laval University, Canada Carmen Silvia Valente Barbas, University of São Paulo, Brazil. Gestational hypoxia is a risk factor in the development of pulmonary hypertension in the newborn and other sequela, the mechanisms associated with the disease remain poorly understood. This review highlights disruption of metabolism by antenatal high altitude hypoxia and the impact this has on pulmonary hypertension in the newborn with discussion of model organisms and human populations. There is particular emphasis on modifications in glucose and lipid metabolism along with alterations in mitochondrial function. Additional focus is placed on increases in oxidative stress and the progression of pulmonary vascular disease in the newborn and on the need for further exploration using a combination of contemporary and classical approaches
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