Abstract
Abstract Gestational hypothyroidism affects fetus neurodevelopment and leads to cognitive deficiencies. In rodents, this condition also affects the central nervous system and produces differences in the amount and type of immune cells in spleen. We wanted to study if the offspring gestated under hypothyroidism have alterations in the performance and/or activation state of the immune cells during an infection. To evaluate this, we studied the immune response against the pathogen Streptococcus pneumoniae in female mice gestated in hypothyroid mothers (hypo mice) and in control mothers (untreated mice), which were infected intranasally to cause pneumonia. A survival curve showed that hypo mice were more resistant to the infection. Hypo mice also showed an increase in the IL-17 levels in BALF. Other parameters such as immune cell populations, histopathology, and bacterial load were also evaluated. For the first time, our study addresses whether there is a correlation between gestational hypothyroidism and the functionality of the offspring immune cells during an infection.
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