Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers.

Barbara Wróblewska,Magdalena Zakrzewska,Ewa Romaszko,Anna Maria Ogrodowczyk

doi:10.3390/nu12082381

Barbara Wróblewska, Magdalena Zakrzewska + Show 2 more

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https://doi.org/10.3390/nu12082381

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Abstract

Background: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of antibodies in the offspring’s serum. Methods: 153 allergic and 150 healthy individuals were diagnosed for allergy using specific antibody and cytokine immunoassay tests. The medical history of subjects along with mothers’ course of pregnancy was completed by allergologist’s anamnesis. A self-organizing neural network and multivariate analyses to complex data and pick basic interactions were used. Results: Two significant explanatory modules were determined. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters). The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters). Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity.

Highlights

The human immune system is immensely complex but is not always able to develop tolerance to food allergens
Of the 153 allergic patients enrolled in this study, subjects suffering from allergy to a single food-origin allergen (SFA) and polyallergy to various food-origin allergens (PFAs) were 31% each (Figure 1)
The most common method for complex data projection in this area is the t-distributed stochastic neighbour embedding (t-SNE), but this approach might be frequently unreliable in the context of biomedical, cytometry data analysis because of the incorrect number of subgroups or projected data points belonging to different subgroups, as if they belong to the same subgroup

Summary

Introduction

The human immune system is immensely complex but is not always able to develop tolerance to food allergens. The drawback of developing an immune system that may recognize and respond to infections is the potential for hypersensitivity reactions. These manifest as allergic responses to environmental agents among others. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters). The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters). Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity

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