Abstract
Geropotency: Increased malignant potential of aging neural progenitors
Highlights
In human adult gliomas increased patient age is a robust predictor of malignant clinical behavior evidenced by increased incidence, histologic grade, resistance to therapy and shortened patient survival [1]
These observations suggest that aging related changes in putative glioma cells of origin contribute to increased malignant potential
After malignant transformation the age-dependent state of malignant “pre-conditioning” present in normal NSPCs translates into differential growth advantages within the brain and glioma micro-environment
Summary
In human adult gliomas increased patient age is a robust predictor of malignant clinical behavior evidenced by increased incidence, histologic grade, resistance to therapy and shortened patient survival [1]. These observations suggest that aging related changes in putative glioma cells of origin contribute to increased malignant potential. Many aging associated changes observed in normal NSPCs would seem more likely to inhibit malignant potential.
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