Abstract
The mouse study of Johnson et al. (Nature 2004, 428: 145-150) may suggest that the prosimian primates are not the only mammals to exhibit mitotically active germ cells in adult ovaries. If the dogma is to be debunked and a new one accepted, at least in the mouse, it is sure to be challenged and tested, as should all dogma.
Highlights
Germline stem cells in the postnatal mammalian ovary: A phenomenon of prosimian primates and mice? Evelyn E Telfer*
The paper by Johnson et al "Germ line stem cells and follicular renewal in the postnatal mammalian ovary" published in Nature on the 11th of March [1] suggests that a population of germ line stem cells exist within the adult mouse ovary and that oocyte numbers are regulated by a balance of activation of these cells and cell death
Further evidence using tritiated thymidine labelling of oocyte nuclei supported the view that juvenile and adult ovaries are direct descendants of the fetal germ cells and that germ cells do not increase in number throughout life [7,8,9]
Summary
Germline stem cells in the postnatal mammalian ovary: A phenomenon of prosimian primates and mice? Evelyn E Telfer*. Germline stem cells in the postnatal mammalian ovary: A phenomenon of prosimian primates and mice? The paper by Johnson et al "Germ line stem cells and follicular renewal in the postnatal mammalian ovary" published in Nature on the 11th of March [1] suggests that a population of germ line stem cells exist within the adult mouse ovary and that oocyte numbers are regulated by a balance of activation of these cells and cell death.
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