Abstract
OPINION article Front. Neural Circuits, 16 October 2013 Volume 7 - 2013 | https://doi.org/10.3389/fncir.2013.00168
Highlights
Conditional gene targeting allows us to study gene function in specific tissues or cell types
We show an example of the undesired recombination in a Cre line whose expression is controlled by the parvalbumin (Pvalb) promoter
In the Pvalb-IRES-Cre+/− background, EYFP was slightly expressed in Leydig cells, EYFP was absent from spermatids (Figures 1D,E)
Summary
Conditional gene targeting allows us to study gene function in specific tissues or cell types. We show an example of the undesired recombination in a Cre line whose expression is controlled by the parvalbumin (Pvalb) promoter. Both Cre lines have been widely used to induce or delete genes of interest in parvalbumin (PV)positive GABAergic neurons in the brain.
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