Germline Genetic Modification

Abstract

For several decades, scientists and ethicists have considered the possibility of altering genes at the beginning of human life. Human germline genetic modification began to attract widespread attention as early as the 1960s (Evans 2002: 55–57). At that time, scientists and scholars began examining the benefits and harms that could come from attempting to alter genes at the earliest stage of human development.This chapter describes the general arguments for and against human germline modification, but it analyzes germline genetic modifications from a vantage point that differs from most ethics and policy discussions. Writers addressing the topic often limit their discussions to the benefits and harms that could materialize if germline modifications were widely available. In this chapter, however, I consider the technology as it stands today. The question for contemporary society is not whether it would be a good or a bad thing if germline modifications were performed in humans. Instead, today’s ethical inquiry should focus on whether to pursue human germline genetic intervention as a research goal. For us, the relevant questions are the following: What is the potential value of research aimed at human germline genetic modification and what price would be paid in attempting to develop the technology?