Gerinnungsdiagnostik im klinischen Alltag – Teil 1

Abstract

This article on coagulation diagnostics is published in two parts covering five common clinical scenarios for coagulation diagnostics. Part1 deals with the diagnostics prior to invasive interventions and coagulation diagnostics to clarify atendency to bleeding. The global parameters Quick and activated partial thromboplastin time are established for monitoring certain anticoagulants; however, they are not predictive with respect to the risk of bleeding prior to elective invasive interventions. In this context, disorders of primary hemostasis are frequent, which are insufficiently detected by the global parameters. Most clinical bleeding tendencies are due to acquired causes. These include anticoagulants and diseases which can be accompanied by tendency to bleeding. For coagulation tests preanalytical issues are essential in order to avoid false results. The interpretation should always be made in the context of the current physiological state.