Abstract
Evidence is presented that expression of the cotH gene, whose product is required for the correct assembly of the Bacillus subtilis spore coat, is negatively controlled by the transcriptional regulator GerE. Mutations in the GerE-box, present in the cotH promoter region, increased expression of this gene, which also remained elevated during late stages of sporulation, when in wild-type cells cotH is normally turned off. Such alterations of cotH expression did not significantly affect spore coat structure or function but caused the accumulation of CotC molecules in the mother cell compartment, most likely as a consequence of CotH-mediated protection of CotC.
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