Abstract
Background: Aluminum (Al) is a ubiquitous environmental toxicant associated with adverse effect on the testis. Thus, we investigated the protective effect of GER against Al-induced testicular injury and endocrine-sperm deficits in male rats. Methods: Adult male rats were randomly divided into 4 groups: Control group, GER group (100 mg/kg body weight for 28 consecutive days, orally), Al group (200 mg/kg body weight every 3 days for 28 days, ip) and GER + Al group (100 mg/kg + 200 mg/kg). Levels of testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured in serum. Testicular parameters of oxidative stress, inflammation and apoptosis were analysed, as well as sperm parameters and testis histology. Result: The Al exposure significantly (p less than 0.05) decreased levels of T, LH, FSH, IL-4 and IL-10, whereas Al increased oxidative stress, inflammation and apoptotic markers compared to the control. Al induced marked histopathological abrasions and caused adverse effects on sperm parameters compared to the control. On the contrary, the co-administration of GER with Al ameliorated the Al-induced endocrine-sperm deficits, testicular oxidative stress, cytokine inflammation and apoptosis. GER is a potential natural monoterpene for prevention of Al-induced testicular toxicity and endocrine-sperm dysfunction in rats.
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